Overview: The aim of a crystallization process is to produce the optimal form of a solid with all of the desired properties such as particle size, particle shape, bulk density, purity, yield, and residual solvent content. Developing a process to achieve this goal requires multiple steps. This informative C&EN webinar will examine the steps that include:
- A salt and/or co-crystal screening and characterization to identify the optimal salt or co-crystal.
- A polymorph and solvate screening of the desired substance to identify, characterize, and determine the thermodynamic relationships of all relevant forms.
- Arrival at a final selection of optimal form, which is often the thermodynamically stable form at room temperature or a hydrate.
A small-scale (10-250 mL) process is then developed to obtain the selected optimal form in the desired particle size distribution; yield, purity, and other crystallization parameters are optimized at this stage. Often, a seeded crystallization process is required to deliver optimal control. This process is then further scaled up in a kilo-lab, followed by production on a kg-scale in a GMP-facility. Quick communication and efficient know-how transfer between the scientists of the various disciplines assures a very efficient and fast process.
In this webinar, participants will learn:
- Logical approach to form selection.
- Examples for form characterization (critical water activity).
- How to develop a crystallization process.
- Important parameters of a crystallization process.
- Required toolbox.
- Case studies.
Who should attend?
- Those interested in automated, offline SPE and GC/MS.
- Lab managers and directors of chemical and pharmaceutical development.
Rolf Hilfiker, Ph.D.,
Head of Department of Solid-State Development